SOX2 and neoplasm: While our study uncovers that copper depletion by altering metabolic reprogramming of select population of SOX2/OCT4+ metastatic cells that reside in the primary tumor, as a potential antimetastatic therapeutic strategy, it has been reported that in the context of metastasis, copper also serves as a critical co-factor for lysyl oxidase that has been implicated in the establishment of the premetastatic niche61.