Bioinformatics analyses revealed an expansion of the 20 more-represented TCR rearrangements in mice receiving CT26 with Ppp2r1a knockdown tumour cells (Fig. 4h and Supplementary Table 6), suggesting that Ppp2r1a knockdown in mouse MSS CRC triggers neoantigen generation and sensitises them to ICB-mediated anti-tumour activity. Here, PPP2R1A is linked to colorectal carcinoma.