Based on the consensus molecular subtypes (CMSs) of CRC49, the majority of MSI tumours belong to type I CMS (characterised by increased expression of genes associated with a diffuse immune infiltrate, mainly composed of TH1 and cytotoxic T cells), while tumours caused by Apcfl/fl, KrasLSL-G12D, Tgfbr2fl/fl, and Trp53fl/fl, belong to type IV CMS (characterised by TGFβ-activated stroma)50 are corresponding to MSS, suggesting the tumour itself is the dominant force shaping the tumours microenvironment. This evidence concerns the gene TGFB1 and neoplasm.