Furthermore, immunoblot analyses indicated appreciable IRE1α-dependent downregulation of proteins encoded by several of the above mRNAs in Tg-treated MDA-MB-231 cells (Supplementary Fig. 1f); or in AMO1 and KMS27 human multiple myeloma cells displaying constitutive phospho-IRE1α and XBP1s (Supplementary Fig. 1g, h). The gene discussed is ERN1; the disease is plasma cell myeloma.