VIMENTIN expression was predominantly on the cell membrane in CI-HS and non-treated CFH(Y/Y) and CFH(H/H) iRPE cells but was missing from the cell membrane and did not form an organized cytoskeleton network in elongated CC-HS treated CFH(Y/Y) and CFH(H/H) iRPE cells (arrowheads, Fig. 2j, k and Supplementary Fig. 2c, d), similar to RPE dedifferentiation seen at the borders of GA lesion in cadaver AMD eyes (Supplementary Fig. 2e–h). Here, VIM is linked to age-related macular degeneration.