In both CFH(Y/Y) and CFH(H/H)-iRPE, the AMD disease phenotypes are mediated by C3a–C3aR1 and C5a–C5aR1 signaling-induced NF-κB activation, autophagy downregulation, and dysregulated intracellular calcium homeostasis. This evidence concerns the gene C5AR1 and age-related macular degeneration.