Published GWAS studies have demonstrated that two risk alleles have the highest associations with AMD—rs10490924, T/T in locus ARMS2/HTRA1 and rs1061170, C/C (leading to a homozygous substitution of amino acid tyrosine (Y) to histidine (H) at location 402) in gene CFH19,20. The gene discussed is HTRA1; the disease is age-related macular degeneration.