CFH and age-related macular degeneration: To develop an in vitro AMD model that works with all three categories of CFH alleles, we tested four iPSCs lines with high-risk allele CFH(H/H), three iPSC lines with the low-risk allele CFH(Y/Y), and three iPSC lines heterozygous for the allele CFH(Y/H)21 (Supplementary Table 1 and Table 1).