A set of genes associated with neuropsychiatric conditions, including Alzheimer’s disease (CLU, P4HA1), schizophrenia (CNIH2, DKK3), and autism-spectrum disorders (SEZ6L, SDC2), was found particularly upregulated in this cluster (Fig. 3h)40. The gene discussed is P4HA1; the disease is early-onset autosomal dominant Alzheimer disease.