PCAT1 and posterior cortical atrophy: Further evidence supporting a direct stimulatory effect of AR was obtained from ENCODE H3K27ac ChIP-seq datasets on cell lines, which showed that only the two AR-positive PCa cell lines (LNCaP and VCaP), and not two AR negative PCa cell lines (PC3 and DU145), had robust H3K27ac signals over the PCAT1 gene, and that these were in alignment with AR tracks (Fig. S9c).