NLGN1 and Familial prostate cancer: To profile the spatial heterogeneity of NRXN1 and NLGN1 expression across distinct cell types, we marked basal (CK5, CK14), luminal (CK8) and neuroendocrine (Chromogranin A) epithelial cells within the prostate glands, as well as the endothelial (CD31), neuronal (NCAM) and immune cells (CD45, CD3) in the prostate cancer microenvironment (Fig. 5 and Supplementary Fig. 11).