In parallel to our observations, we found FOXA1, HOXB13 and CDX2 to be highly enriched in prostate tumours with primary Gleason pattern 4 (Gleason score 4 + 4 and 4 + 5 patients) as compared to tumours that are predominantly Gleason pattern 3 (Gleason score 3 + 4) (Fig. 4c). Here, CDX2 is linked to prostate neoplasm.