We found low-grade prostate tumours were significantly enriched for the AP-1 family of TF binding sites (JUN, JUNB, JUND and FOS, FOSB and FRA1, and the closely related activating TFs: ATF and CREB), in contrast to high-grade prostate tumours that were enriched for FOXA1, HOXB13 and CDX2. The gene discussed is FOS; the disease is prostate neoplasm.