STAT3 and Alzheimer disease: In total, our in vitro and in vivo data implicating STAT3 in CAA pathogenesis and CAA-induced cerebrovascular deficits represent a significant advancement, as they strongly suggest STAT3 not only plays a causal role in the parenchymal pathology and Aβ-related deficits of AD, but that it also contributes to the vascular pathology and dysfunction associated with AD-related dementia.