Similarly, a transient reduction of WNT11 expression by siRNA (Fig. S3b) resulted in decreased tumor cell invasion in MCF-7 and BT-474 pROR2 cells (Fig. 4d+e), an effect that was rescued by addition of recombinant WNT11 (Fig. 4d), thus confirming that WNT11 mediates a major part of the invasion-promoting effect of ROR2. This evidence concerns the gene ROR2 and neoplasm.