Compared with normal pancreatic tissues, the high expression of KLF4 and FOXA1 in PCa tissues was also exhibited in Additional file 1: Fig. 1B, C. To ascertain the transcription factor, we respectively knocked down KLF4 and FOXA1, discovering that MIR99AHG expression was regulated only by FOXA1 (Fig. 2A). Here, FOXA1 is linked to posterior cortical atrophy.