The key role of JNK in the regulation of AMPA receptor membrane insertion [57] and in PSD95 stability [58] as well as the D-JNKI1 neuroprotective effect has been previously described in Alzheimer’s diseases [26–28, 59–61] and also in an Angelman Syndrome mouse model [62]. Here, MAPK8 is linked to early-onset autosomal dominant Alzheimer disease.