IHC analysis showed that MFC-sh-circDLG1-derived tumors were associated with increased CD8+ tumor-infiltrating lymphocytes (TILs) and decreased infiltration of Gr-1- and CD11b-positive MDSCs (Gr-1 and CD11b are mouse MDSC markers) (Fig. 4c, Additional file 8: Fig. S4). Here, ITGAM is linked to neoplasm.