Decreased HDL levels associated with increased sensitivity toward inflammatory stimuli as reflected by enhanced inflammatory and coagulation responses on endotoxin challenge [35] Porphyromonas gingivalis (P. gingivalis), a gram-negative oral anaerobe involved in the pathogenesis of periodontitis, induces oxidation of HDL [36], and lipopolysaccharide from P. gingivalis suppresses the secretion of adiponectin from adipocytes [37]. Here, ADIPOQ is linked to periodontitis.