Based on the results of the HCC tissue microarray, HOXD9 and HOXD10 expression was higher in the HCC tissues with MVI (n = 140) than in HCC tissues without MVI (n = 120) (P < 0.001) (Figs. 6A, B and 7A, B). This evidence concerns the gene HOXD9 and hepatocellular carcinoma.