WEE1 and migraine disorder: The following pathway to provoke migraine-like headache has currently been proposed for GTN; nitric oxide released by GTN activates intracellular soluble guanylate cyclase, which catalyzes the formation of cyclic guanosine monophosphate (cGMP) an important second messenger involved in the activation of various protein kinases, implicated in smooth muscle relaxation and vasodilatation (Ashina et al., 2017).