CD19 and hematologic disorder: Specifically, within the realm of currently approved CAR-T therapies for hematologic malignancies, the CD19-directed CAR-T lisocabtagene maraleucel (Bristol Myers Squibb, formerly developed by Juno Therapeutics) is distinct from other approved CAR-T products because the final cell product is designed to have an equal ratio of CD4+ and CD8+ T cells, both engineered to recognize CD19 in an antigen-independent fashion.