One of the earliest reports involved selection and expansion of clonal autologous CD4+ T cells from a melanoma patient recognizing an epitope from a shared cancer-testis antigen (NY-ESO-1) presented in the context of HLA-DPB1*0401; infusion of these cells led to a long-term complete response (Hunder et al., 2008). This evidence concerns the gene CD4 and melanoma.