Removal of Sarm1 or the presence of Wallerian degeneration slow (WLDS) (or other overexpressed NMNATs, which negatively regulate programmed axon degeneration) show promise in preventing disease progression in models of FTD (Ali et al., 2012; Ljungberg et al., 2012; White et al., 2019). This evidence concerns the gene SARM1 and frontotemporal dementia.