Drugs that inhibit the activity ofcholinesterases have emergedas leading symptomatic treatments for the early stages of Alzheimer’sdisease to date.7 In the early stages ofAlzheimer’s disease, patients have enhanced AChE activity,resulting in decreased acetylcholine levels in the brain.8 The results of some studies show that with theprogression of Alzheimer’s disease the expression of AChE decreases,while the expression of BChE begins to increase in specific brainareas. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.