In the current study, we explored the role of M‐EVs containing miR‐19b‐3p in atherosclerosis and identified that M‐EVs containing miR‐19b‐3p elicited stimulative functions on atherosclerosis development through inhibition of JAZF1 by facilitating the migration and proliferation of VSMCs. This evidence concerns the gene JAZF1 and atherosclerosis.