Similarly, IL-10-producing CD1dhigh CD5+ B cells (B10) were found in the spleen, suppressing CD4+ T cells, dendritic cells (DC), as well as monocytes thereby playing a protective role in a plethora of mouse models including experimental autoimmune encephalomyelitis (EAE) [982, 983], lupus [984], myasthenia-gravis [985], collagen-induced arthritis [986], colitis [987], allergic inflammation [988, 989] and contact hypersensitivity [990]. The gene discussed is IL10; the disease is colitis.