Serum–creatinine (day 1: 97[62–168] vs. 80[62–88] μmol/L, P < 0.001) and urea (day 1: 21[13–31] vs. 10[8–14] mmol/L, P < 0.001) were increased in the CLS group, and prothrombin time (day 1: 41[35–49] vs. 34[29–38] sec, P < 0.001) was prolonged. This evidence concerns the gene F2 and capillary leak syndrome.