IL-33 is highly expressed in the epidermal keratinocytes in AD (Savinko et al., 2012), and IL-33 expression in the epidermis is known to correlate with the severity of skin rashes as indicated by SCORing Atopic Dermatitis and Eczema Area and Severity Index (Guttman-Yassky et al., 2019). The gene discussed is IL33; the disease is Alzheimer disease.