FLG and ichthyosis: Thus, FLG deficiency per se does not alter lipid or glucose metabolism in KCs, and the abnormalities in LB cargo composition observed in FLG-deficient mice, similar to what has been observed in patients with various ichthyoses, might rather result from cytoskeletal abnormalities, as suggested earlier (Elias and Wakefield, 2014; Gruber et al., 2011; Reynier et al., 2019).