However, an enhanced PPARδ pathway induced by an impaired epidermal barrier (Blunder et al., 2021; Michalik et al., 2003; Tsai et al., 1994; Wood et al., 1992) might significantly contribute to ACOX1 upregulation (Higgins et al., 2012; Luquet et al., 2005) in both ADL- and psoriasis-like inflammation (Yamane et al., 2009). Here, ACOX1 is linked to psoriasis.