Likewise, MAP3K8 is a key regulator of the innate immune response (Arthur and Ley, 2013) and is responsible for activation of extracellular signal–regulated kinase 1/2 and p38 MAPK, whose expression have been implicated in skin inflammation in response to irritants in in vivo experimental models (Pastore et al., 2005) and in reconstituted HSE (Frankart et al., 2012). Here, MAP3K8 is linked to dermatitis.