To resolve the molecular signatures of Th2 cells and ILC2s from patients with AD before and after dupilumab treatment, we sorted CD4+ T cells and ILCs from peripheral blood and analyzed their transcriptomes using the BD Rhapsody scRNA-seq analysis system (BD Biosciences, San Jose, CA) (Figure 3a–h) (Hasegawa et al., 2019). This evidence concerns the gene CD4 and Alzheimer disease.