A different acid which is thought to interfere with TGF-β signaling is salvanic acid B. A study performed in a mouse model of myocardial fibrosis confirmed that TGF-β and Smad2/3 were increased during fibrosis, with the antifibrotic Smad7 being decreased (Gao et al., 2019). The gene discussed is TGFB1; the disease is Myocardial fibrosis.