Barreyro et al. (2015) used the pan-caspase inhibitor emricasan to target caspase-1, one of the essential proteins needed for IL-1 maturation. By assessing markers of liver damage, i.e. aspartate aminotransferase and alanine aminotransferase, these investigators suggested that emricasan can reverse liver fibrosis induced by a high-fat diet. Inflammatory markers were also tested for, including IL-1β, with emricasan-treated mice expressing significantly less IL-1β when measured by qPCR (Barreyro et al., 2015). The gene discussed is IL1B; the disease is Hepatic fibrosis.