For example, E protein from SARS-CoV-1 has been shown to bind to human ATP pump subunit ATP1A1 [10]; the yeast orthologue of ATP1A1, Ena2, has a SPI with SARS-CoV-2 E. Consequently, our data show that the SPIs produced by the SARS-CoV-2 proteins in yeast can indicate their sites of function during viral infection in mammalian cells. The gene discussed is ATP1A1; the disease is viral infectious disease.