Furthermore, TLR3 and TLR4 are specifically related by different studies as part of immune response in COVID-19 (Patra, Chandra Das & Mukherjee, 2021; Khanmohammadi & Rezaei, 2021; Kaushik, Bhandari & Kuhad, 2021). This evidence concerns the gene TLR4 and COVID-19.