Given the conserved functions of Cul3–inc complexes and the associations of Cul3 lesions with autism (Kong et al., 2012; Li et al., 2017; O’Roak et al., 2012), elucidating inc substrates and their contributions to neurogenesis and neuronal anatomy may provide insights into brain development, tumorigenesis, and sleep disorders. Here, CUL3 is linked to sleep disorder.