Although VRs with TB had higher IP-10 levels at baseline (median 1106 pg/ml [IQR, 627–1,704]), compared with individuals without TB (median 628 pg/ml [IQR, 391–885]; P = 0.003), the rate of IP-10 decline during ART was similar, regardless of TB-status. Here, CXCL10 is linked to tuberculosis.