& Netsky, 1953; Nihei, McKee, & Kowall, 1993), astrocytic gliosis (Kamo et al., 1987; Murayama, Inoue, Kawakami, Bouldin, & Suzuki, 1991), and aberrant TDP‐43 deposition (Brettschneider et al., 2013) are considered the core pathological features in the motor cortex in ALS. Here, TARDBP is linked to amyotrophic lateral sclerosis.