IFNG and infection: Primarily, T helper 1 (Th-1) cell-mediated protective immunity to T. gondii drives the production of high levels of interleukin-12 (IL-12) and interferon-γ (IFN-γ) followed by the migration of innate immune cells (e.g., DCs, macrophages and neutrophils) to the site of infection, which are indispensable for host resistance against T. gondii, and limiting the parasite’s proliferation and the progression of infection via multiple intracellular mechanisms with the production of various antiparasitic factors [13, 23].