It can suppress the proliferation, migration and invasion of HCC cells and induce HCC cell apoptosis via down‐regulating a number of target genes, such as T‐cell factor‐4 (TCF‐4), Rho‐kinase 2 (ROCK2), zinc finger E‐box‐binding homeobox 1(ZEB1) and 2 (ZEB2).138. This evidence concerns the gene TCF4 and hepatocellular carcinoma.