Taken together, this study has discovered a novel mechanism for β‐catenin/TCF‐4‐LINC01278‐miR‐1258‐Smad2/3 feedback loop activation in HCC metastasis and provides support for the potential of LINC01278 as a therapeutic target in HCC.123. Here, LINC01278 is linked to hepatocellular carcinoma.