TTR and cardiac sarcoidosis: If focal ATTR amyloid deposition in patients with early-stage ATTR-CA can be detected early, new life-prolonging drugs would be of greater benefit.4 Although Miller et al used a threshold, determined as 1.5 × left ventricular blood pool (LVBP) 99mTc-PYP activity in SPECT, their method was based on previous studies of 18F-fluorodeoxyglucose positron emission tomography with suspected cardiac sarcoidosis patients.7 As shown by our results of CPV1.4, higher thresholds can cause false-negative diagnosis in patients with focal abnormal uptakes.