In the human genome, exceptionally long introns are found in genes with a wide variety of cellular and developmental functions, including genes with important roles in some diseases, e.g., dystrophin in DMD and cystic fibrosis transmembrane conductance regulator (CFTR) in cystic fibrosis (CF) (Sterrantino et al. 2021). Here, CFTR is linked to Duchenne muscular dystrophy.