CDNF and Parkinson disease: Nadella et al. [109] found that in the 6-OHDA-lesioned rats, CDNF overexpressed from a plasmid vector reduced nitrosative stress, glial markers, and IL-6 levels in the SN, but not TNFα and IL-1β levels, suggesting that CDNF may be a potential novel agent for the treatment of neuroinflammation seen in the PD.