TP53 and neoplasm: We extracted from the UMD TP53 mutation database (https://p53.fr/tp53-database) a total of 1209 TP53 missense mutations, that were identified in patient tumor samples at least once and map to the DNA binding domain (aa100-300), along with their transcriptional activity as measured in a yeast-based reporter assay using response elements (REs) of 8 prototypical p53 target genes [10].