Due to excessive lung injury and abnormal repair, excessive release of MUC5B can lead to the exacerbation of IPF14,20–22.SNP rs35705950 is a G to T trans version in the 5 'flanking region of MUC5B 3 kb upstream of the transcription initiation site, it shows the strongest association with IPF14.In the Caucasian population, 41.9% of IPF patients and 10.8% of the control group had the T-risk allele11, while in the Chinese population, the frequency of T allele was about 3.33% in IPF patients and 0.66% in the control group23. Here, MUC5B is linked to idiopathic pulmonary fibrosis.