Thus, there are many advantages of mitochondria as molecular targets14: (i) as mitochondria are the powerhouse of the eukaryotic cell, a disruption of the mitochondrial function stops the rapid growth of cancer cells; (ii) the mitochondrial release of cytochrome c results in the activation of the caspase-dependent apoptotic pathway; (iii) the nucleotide excision repair (NER) pathway, reducing the efficacy of any nuclear DNA targeting anticancer drug, is avoided; and (iv) plausible perturbations in many important cancer cell metabolism pathways. Here, CYCS is linked to cancer.