AKT1 and cancer: Consistent with the Uniform manifold approximation and projection (UMAP) done by Corsello et al.7 on the pan-cancer cell lines, some of the targeted compounds consistently show strong clustering-this includes the EGFR inhibitors, MEKi, PI3K/AKT/MTOR inhibitors, multi-tyrosine kinase inhibitors (mTKIs) and Aurora kinase inhibitors [Fig. 2D].