MKI67 and cancer: Considering the potency of 43 °C to induce the synthesis of nuclear factor Ki-67 and stimulate colorogenic capacity and autophagic response in the SH-SY5Y cells (Fig. 6A), we could hypothesize that the incubation of cancer cells in mild temperatures could inhibit active dynamic growth but simultaneously promote autophagic response which is a compensatory response to resist again insulting stimuli.