Data showed that except Atg12, Atg5 and Atg16L were up-regulated in the neuroblastoma cell line during exposure to 43 °C (Atg5: 2.63-fold and Atg16: 2.94) and 48 °C (Atg5: 1346.50-fold and Atg16: 1164.10-fold) (Fig. 6D, Supp. Here, ATG16L1 is linked to neuroblastoma.