Furthermore, several c-aAbs were associated with disease type; IL-1α c-aAbs levels were higher in patients with nonmalignant disease (P = 0.050), and the proportion of nonmalignant patients with high-titre levels of GM-CSF and IL-10 c-aAbs was elevated (86% of high-titre individuals, P = 0.032 in both cases), whereas all individuals with high-titre IFNγ c-aAbs had malignant disease (P = 0.013). The gene discussed is IL1A; the disease is glycogen storage disease VI.