Also noteworthy are the two IL7R-triggered Ph-like ALL transcriptional subgroups, one of which (Ph-like 1) displays Cdkn2a deletions, Kras mutations and Gins2 gains and the other (Ph-like 2) mutations in genes encoding histone methyltransferases (Kmt2d, Suv39h1) and histone subunits (H3f3b and Hist1h3). Here, KMT2D is linked to acute lymphoblastic leukemia.