CD4 and neoplasm: There was a significant increase in the expression of OX40 on tumor-infiltrating CD8+ T cells and dendritic cells (DCs) following PL1-OX40 treatment (Fig. 3f and Supplementary Fig. 11a), but there were minimal changes in the OX40 expression on infiltrating CD4+ T cells or macrophages (Supplementary Fig. 11a).