PIK3CA and cancer: For instance, HL-60 cells showed strong selective response to the pan-PI3K inhibitor (higher potency toward α and δ isoforms) pictilisib (Fig. 5b) in line with data from the Genomics of Drug Sensitivity in Cancer portal (GDSC1)36, where pictilisib was tested across 937 cell lines and HL-60 scored as 20th most sensitive cell line (Supplementary Fig. 7a).