For instance, cell lines harboring activating mutations in the RAS genes (groups III and group V) were predominantly glycolytic and displayed lack of sensitivity to mTOR and mitochondrial respiration inhibitors in line with previous reports that RAS-mutated cancers display a Warburg effect phenotype exemplified by increased glucose utilization and lactate production, and upregulation of the glucose transporter SLC2A151–54. Here, MTOR is linked to cancer.