SYT8 and neoplasm: Furthermore, when siSYT8-expressing or SYT8-overexpressing BxPC-3 or PANC-1 cells were transferred to BALB/c nude mice and monitored for tumor growth, we observed a significant decrease in tumor size over 6 weeks in the siSYT8-expressing mice compared to an increase in the SYT8 overexpression group (Fig. 2F).