The expression of G-CSF and GM-CSF were also increased upon B.1.351 infection, which promoted the proliferation and maturation of neutrophils, macrophages, and eosinophils (p = 0.0087 for G-CSF in hACE2 on Day 2, p = 0.0004 for G-CSF in BALB/c on Day 2; p = 0.0223 for GM-CSF in BALB/c on Day 2). The gene discussed is CSF3; the disease is infection.