These frequencies do not include recurrent founder PVs observed in controls at a frequency exceeding the MTAFpred threshold, namely SDHB c.286G>A p.Gly96Ser (frequency of 17 in cases and 2 in v2.1.1 [non-cancer]NFE), SDHB c.688C>T p.Arg230Cys (frequency of 10 in cases and 2 in v2.1.1 [non-cancer]NFE), SDHB c.725G>A p.Arg242His (frequency of 19 in cases and 3 in v2.1.1 [non-cancer]NFE), and SDHD c.242C>T p.Pro81Leu (frequency of 116 in cases and 4 in v2.1.1 [non-cancer]NFE). Here, SDHD is linked to cancer.