Non-treated female NOD mice showed signs of T1DM from 16 weeks of age and the incidence of T1DM increased to approximately 90% at 35 weeks of age [24]; however, treatment of the female prediabetic NOD mice with DNA nanoparticles (DNPs) (activators of STING) at 4–8 weeks delayed the progression of T1DM, owing to which all mice remained disease-free until 27 weeks of age. The gene discussed is STING1; the disease is type 1 diabetes mellitus.