BRCA1 and obesity due to melanocortin 4 receptor deficiency: While the rate of germline BRCA1/2 mutations in patients with breast cancer is similar across racial/ ethnic groups; obesity, higher parity, younger age at first birth, and early weaning or never-having breast fed are more prevalent among AA than white women and may significantly contribute to increased inflammation and to higher TNBC incidence in AA women [9, 10].